![]() ![]() All animals were tested for the neurobehavioral parameters throughout the 6 weeks of the study. ![]() The crush groups III, IV and V underwent sciatic nerve crush injury, followed by treatment daily for 14 days with saline, SPF-FB IP and SPF-FB SC. ![]() Male rats were randomly assigned to five groups: (I) NAÏVE, (II) SHAM, (III) CRUSH treated with saline, (IV) CRUSH + SPF-FB treated with 3 mg/kg intraperitoneally (IP) and (V) CRUSH + SPF-FB treated with 6 mg/kg subcutaneously (SC) groups. Here, we report for the first time a unique preparation containing only proteins and lipids (soluble protein fraction B, SPF-FB), derived from the PCEGS accelerated the healing and recovery of sensory-motor functions of experimental sciatic nerve crush injury in rats with its unique neuroprotective and neuroregenerative properties on the spinal neurons and peripheral nerve fibers. Preliminary investigations showed that preparations from Arabian Gulf catfish ( Arius bilineatus, Val) epidermal gel secretion (PCEGS) exhibit potent anti-inflammatory and healing properties as shown in our previous clinical trials for the healing of non-healing diabetic foot ulcers, chronic back pain, and some other neurological disorders. 2Biological Sciences, Faculty of Science, Kuwait University, Safat, Kuwait.1Department of Anatomy, Faculty of Medicine, Kuwait University, Safat, Kuwait.Renno 1*, Mohammad Afzal 2, Bincy Paul 2, Divya Nair 2, Jijin Kumar 1 and Jassim M. ![]()
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